Endocrine Abstracts

Introduction: VATER syndrome is a rare, usually sporadic, entity, including ≥2 of the following: vertebral defects (V), anal atresia (A), tracheoesophegeal fistula, esophageal atresia (TE) and radial or renal dysplasia (R).Maturity onset diabetes of youth (MODY) is a usually non-insulin-dependent type of monogenic diabetes mellitus (DM), usually in adults <25 years, with autosomal dominant inheritance, without the features of metabolic syndrome...

Introduction: Discontinuation of denosumab may rarely lead to rebound fractures, although the evidence is low, since available data have derived from case reports and post-hoc analyses.Case presentation: A 45-year old Caucasian male was presented at the outpatient clinic in February 2016 for evaluation and management of severe osteoporosis, which had been complicated with multiple vertebral low energy fractures at the 10 th to 12th ...

Introduction: Parathyroid cysts constitute a rare cause of primary hyperparathyroidism (PHPT). PHPT may also rarely coexist with non-medullary thyroid carcinoma (NMTC).Case presentation: A 70-year old woman was admitted to our department for type 2 diabetes mellitus (T2DM) management. She also reported nephritic colics due to kidney stone disease. There were no reports for fractures, symptoms of hypercalcemia or obstructive neck symptomatology. Laborator...

Background: Assessment of hypothalamic–pituitary adrenal axis in patients with schizophrenia is complex, as it involves both the disease process and antipsychotic medications. We present a case of a patient on long term clozapine with a concomitant pituitary adenoma who presented discordant responses to adrenal stimulation.Case: A 38-year old male was referred with chronic symptoms of reduced libido and associated low testosterone levels. He was tre...

Objective: Parathyroidectomy (PTx) improves quality of life (QoL) in patients with primary hyperparathyroidism (PHPT). Whether this effect is modified according to the patients’ age is unknown. The aim of this study was to evaluate the impact of age on the effect of PTx on QoL and frailty in patients with PHPT, six months post-PTx. Methods: This was a prospective cohort study, including patients with PHPT, admitted from January 2016 to December 2019...

Purpose: Bariatric surgery is very efficacious in treating severe obesity. However, its effect of menstruation and ovulation is currently unknown. The purpose of this study was to assess the effect of gastric sleeve resection (GSR) on menstrual pattern in women with stage III-IV obesity and ovulatory dysfunction compared with conventional management.Methods: This was a prospective, multicentre, non-randomized trial, in premenopausal women, who fulfilled ...

Purpose: Androgens promote early follicular development and granulosa cell proliferation by augmenting follicle-stimulating hormone (FSH) receptor expression in granulosa cells. Several retrospective studies have evaluated the association between basal androgen concentrations and follicular development in women undergoing ovarian stimulation for in vitro fertilization (IVF) with conflicting results. The aim of this study was to investigate whether basal androgen concentrations...

Background: Levothyroxine (LT4-Rx) is one of the most prescribed drugs worldwide and the vast majority of patients receive long-term treatment. However, in a recent study of 291 subjects we found that 60% of this cohort were euthyroid two months after LT4-Rx discontinuation1.Aim of the study: A prospective clinical cohort follow-up study was carried out. In 688 subjects (82% females) aged 48.01±15.96 (range 17-84years) with 8.59±6.98...

Purpose: Thyroid cancer (TC) is the most common endocrine cancer worldwide, affecting mainly women of the reproductive age. However, no data exist with regard to its association with endometrial or uterine disorders. The aim of this study was to assess the risk of hyperproliferative pathology of the reproductive system in female TC survivors.Methods: This was a cross-sectional study in female patients, aged 20-45 years, diagnosed with papillary TC (PTC) ...

Background: Levothyroxine (LT4Rx) is one of the most prescribed drugs worldwide the vast majority of patients receive long-term treatment. However, in a recent study of 291 subjects, it was found that 60% were euthyroid 2 months after LT4-Rx discontinuation1.Aim of the study: A prospective clinical cohort follow-up study was carried out. In 688 subjects (82% females) aged 48.01&pm;15.96 (range 17-84years) with 8.59&pm;6.98 years on LT4Rx witho...